Professors

Rongpeng Li

发布者:孙荣发布时间:2018-10-22浏览次数:11

Rongpeng Li

Telephone: 86-18361399458

Email: lirongpeng@jsnu.edu.cn

Education

Ph.D., Nanjing Normal University, 2012

B.S., Nanjing Normal University, 2005

Research Experience

2016.12 – now, Professor, the Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province

2014.03 – 2017.04, Research Scientist, Postdoc, School of Medicine and Health Sciences, North Dakota University, U.S.A

2012.08 – 2014.02, Research Scientist, Postdoc, Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology

  

Research Interests

The Li lab investigates fundamental mechanisms of P. aeruginosa (PA) respiratory infection involving autophagy, epigenetics and ubiquitination, especially during phagocytosis, inflammatory response, and bacterial clearance. The lab studies macrophage function (phagosome maturation) relating to signaling molecules including TLRs, Lyn, annexin A2, caveolin 1, and lipid rafts. The lab also investigates how epigenetic modifications (miRNAs) are associated with pathogenesis of lung infection or other diseases (asthma, chronic obstructive pulmonary disease, and cancer). Considering bacterial virulence and pathogenesis, the lab asks how CRISPR-Cas adaptive immune systems regulate pathogen endogenous gene expression to dictate bacterial invasion and alter the host defense using a combination approach (cell biology, advanced microscopy, negative genetics, and RNA-seq).

The long-term goal is to develop novel therapeutic strategies (e.g., antimicrobial compounds, peptides, and gene delivery) and vaccines (e.g., attenuated bacterial strains) that target to our newly identified signal pathways using new nanoparticles in diagnostics, imaging, and therapy. 

Publications (selected)

[1]Rongpeng Li, Lizhu Fang, Shirui Tan, Min Yu, Xuefeng Li, Sisi He, Yuquan Wei, Guoping Li, Jianxin Jiang, Min Wu*. Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity, Cell Research. 2016, 135:1-15.

[2]Rongpeng Li, Lizhu Fang, Qinqin Pu, Huimin Bu, Pengcheng Zhu, Zihan Chen, Min Yu, Xuefeng Li, Timothy Weiland, Arvind Bansal, Shui Qing Ye, Yuquan Wei, Jianxin Jiang and Min Wu*. MEG3-4 is a miRNA decoy that Regulates IL-1b abundance to initiate and the limit inflammation to prevent sepsis during lung infection. Science Signaling. 2018, 11, eaao2387.

[3]Xuefeng Li#, Sisi He#, Rongpeng Li#, Xikun Zhou, Shuang Zhang, Min Yu, Yan Ye, Yongsheng Wang, Canhua Huang, and Min Wu*. Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration. Nature Microbiology. 2016, 132:1-15.

[4]Rongpeng Li, Shirui Tan, Min Yu, Michael C. Jundt, Shuang Zhang and Min Wu*, Annexin A2 regulates autophagy in Pseudomonas aeruginosa infection through the Akt1-mTOR-ULK1/2 signaling pathway, Journal of Immunology, 2015, 195(8): 3901-11.

[5]Sisi He#, Xuefeng Li#, Rongpeng Li#, Lizhu Fang#, Lingyun Sun, Yongsheng Wang, Min Wu*. Annexin A2 modulates ROS and impacts inflammatory response via IL-17 signaling in polymicrobial sepsis mice. PLoS Pathogens. 2016 12(7): e1005743.

[6]Qinqin Pu#, Cangpei Gan#, Rongpeng Li#, Yi Li, Shirui Tan, Xuefeng Li, Yuquan Wei, Lefu Lan, Xin Deng, Hauhua Liang, Feng Ma and Min Wu*. Atg7 deficiency intensifies inflammasome activation and pyroptosis in Pseudomonas sepsis. Journal of Immunology. 2017, 198: 3205-3213.

[7]Rongpeng Li, Lizhu Fang, Qinqin Pu, Ping Lin, Austin Hoggarth, Huang Huang, Xuefeng Li, Guoping Li and Min Wu*. Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster. Signaling Transduction and Target Therapy. 2016, 2, e16032.

[8]Yuji Jiang, Shuzhen Li, Rongpeng Li, Jia Zhang, Yunhao Liu, Lianfei Lv, Hong Zhu*, Wenlong Wu, Weilin Li. Plant cultivars imprint the rhizosphere bacterial community composition and association networks. Soil Biology & Biochemistry. 2017, 109: 145-155.

[9]Yan Ye, Ping Lin, Weidong Zhang, Shirui Tan, Xikun Zhou, Rongpeng Li, Qinqin Pu, Jonathan L. Koff, Archana Dhasarathy, Feng Ma, Xin Deng, Jianxin Jiang, and Min Wu*. DNA repair interacts with autophagy to regulate inflammatory responses to pulmonary hyperoxia. Journal of Immunology. 2017, 198: 2844-2853.

[10]Xuefeng Li, Sisi He, Xikun Zhou, Yan Ye, Shirui Tan, Shuang Zhang, Rongpeng Li, Min Yu, Canhua Huang*, Min Wu*. Lyn delivers bacteria to lysosomes for eradication through TLR2-initiated autophagy related phagocytosis, PLoS Pathogens. 2016, 12(1): e1005363.

[11]Shuang Zhang, Min Yu, Qiang Guo, Rongpeng Li, Guoping Li, Shirui Tan, Yuquan Wei, Min Wu*. Annexin A2 binds to the endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway. Scientific Reports. 2015; 5: 420–43015859.

[12]Shirui Tan, Changpei Gan, Rongpeng Li, Yan Ye, Shuang Zhang, Yiyan Yang, Weimin Fan, Min Wu. A novel chemosynthetic peptide with b-sheet motif efficiently kills Klebsella pneumoniae in a mouse model. International J Nanomedicine. 2015; 20 (9):755-7.