Weifa Zheng
Professor of Microbiology, Jiangsu Normal University
101 Shanghai Road, Xuzhou ⋅ yyzw@jsnu.edu.cn ⋅ 86-15605219657
Education
Nanjing University, 1993-1996. PhD in natural products chemistry.
East China Normal University, 1986-1989. MD in Botany.
Anhui Normal University, 1982-1986. BD in Biological Education.
Work history
Professor of the Key Laboratory of Biotechnology on Medicinal Plants, Jiangsu Normal University. 2005 to present. Working at fungal genetics and biology.
Visiting scientist, University of Wisconsin-Madison, USA. Oct 2011 to Oct 2012.
Working at fungal genetics and secondary metabolites.
Visiting scientist, University of Latrobe, Australia. Nov 2005 to May 2006.
Working at fungal fermentation and production of polysaccharides.
Postdoc of Nanjing University of Traditional Chinese Medicine, Oct 1996 to Oct 1998.
Working at pharmacology of plant-sourced metabolites
Research interests:
Interaction between fungi and their natural habitats− signal transduction and cellular responses.
Selected publications:
1. Zhao Y, Ding J, Yuan W, Huang J, Huang W, Wang Y, Zheng W*. Production of a fungal furocoumarin by a polyketide synthase gene cluster confers the chemo-resistance of Neurospora crassa to the predation by fungivorous arthropods. Environmental Microbiology. 2017 May 9; 19 (10):3920-3927. doi: 10.1111/1462-2920.13791
2. Zhao Y, He M, Ding J, Xi Q, Loake GJ, Zheng W* Regulation of anticancer styrylpyrone biosynthesis in the medicinal mushroom Inonotus obliquus requires thioredoxin mediated transnitrosylation of S-nitrosoglutathione reductase. Scitific Reports. 2016 Nov 21; 6:37601. doi: 10.1038/srep37601
3. Throckmorton K, Lim FY, Kontoyiannis DP, Zheng W, Keller NP. Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus. Environmental Microbiology. 2016 Jan; 18(1):246-59. doi: 10.1111/1462-2920.13007
4. Zhao Y, He M, Xi Q, Ding J, Hao B, Keller NP, Zheng W*. Reversible S-nitrosylation limits over synthesis of fungal styrylpyrone upon nitric oxide burst. Applied Microbiology and Biotechnology. 2016 May; 100(9):4123-34. doi: 10.1007/s00253-016-7442-7
5. Zhao Y, Xi Q, Xu Q, He M, Ding J, Dai Y, Keller NP, Zheng W*. Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii. Applied Microbiology and Biotechnology. 2015 May; 99(10):4361-72. doi: 10.1007/s00253-014-6367-2.
6. Yuan WH, Wei ZW, Dai P, Wu H, Zhao YX, Zhang MM, Jiang N, Zheng W*. Halogenated metabolites isolated from Penicillium citreonigrum. Chemical Biodiversities. 2014 Jul; 11(7):1078-87. doi: 10.1002/cbdv.201300349
7. Yuan WH, Jiang N, Dong CH, Wei ZW, Wu HK, Chen CF, Zhao YX, Zhou SL, Zhang MM, Zheng W* Lasiodiplodin analogues from the endophytic fungus Sarocladium kiliense. Chem Pharm Bull (Tokyo). 2013;61(3):363-5
8. Shi F, Zeng XN, Cao XD, Zhang S, Jiang B, Zheng W, Tu SJ. Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities. Bioorg Med Chem Lett. 2012 Jan 1; 22(1):743-6. doi: 10.1016/j.bmcl.2011.09.081.
9. Zheng W, Liu Y, Pan S, Yuan W, Dai Y, Wei J. Involvements of S-nitrosylation and denitrosylation in the production of polyphenols by Inonotus obliquus. Applied Microbiology and Biotechnology 2011 Jun; 90(5):1763-72. doi: 10.1007/s00253-011-3241-3.
10. Zheng W, Zhang M, Zhao Y, Miao K, Pan S, Cao F, Dai Y. Analysis of antioxidant metabolites by solvent extraction from sclerotia of Inonotus obliquus (Chaga). Phytochemical Analysis. 2011 Mar-Apr; 22(2):95-102. doi: 10.1002/pca.1225
11. Zheng W, Zhao Y, Zheng X, Liu Y, Pan S, Dai Y, Liu F. Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus. Applied Microbiology and Biotechnology. 2011 Jan; 89(1):157-67. doi: 10.1007/s00253-010-2846-2.
12. Zheng W, Miao K, Liu Y, Zhao Y, Zhang M, Pan S, Dai Y. Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production. Applied Microbiology and Biotechnology. 2010 Jul; 87(4):1237-54. doi: 10.1007/s00253-010-2682-4.
13. Zheng W, Dai Y, Sun J, Zhao Y, Miao K, Pan S, Zhang M, Wei J. Metabolomic analysis on production of antioxidant secondary metabolites by two geographically isolated strains of Inonotus obliquus in submerged cultures. Mycosystema 2010, 29 (6): 897-910
14. Zheng W, Zhao Y, Zhang M, Wei Z, Miao K, Sun W. Oxidative stress response of Inonotus obliquus induced by hydrogen peroxide. Medical Mycology. 2009 Dec; 47(8):814-23. doi: 10.3109/13693780802653933.
15. Zheng W, Miao K, Zhang Y, Pan S, Zhang M, Jiang H. Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus. Microbiology. 2009 Oct; 155(Pt 10):3440-8. doi: 10.1099/mic.0.030650-0.
16. Zheng W, Zhang M, Zhao Y, Wang Y, Miao K, Wei Z. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology. 2009 Feb; 100(3):1327-35. doi: 10.1016/j.biortech.2008.05.002.
17. Zheng W, Campbell BS, McDougall BM, Seviour RJ. Effects of melanin on the accumulation of exopolysaccharides by Aureobasidium pullulans grown on nitrate. Bioresource Technology. 2008 Nov; 99(16):7480-6. doi: 10.1016/j.biortech.2008.02.016.
18. Orr D, Zheng W, Campbell BS, McDougall BM, Seviour RJ. Culture conditions affect the chemical
composition of the exopolysaccharide synthesized by the fungus Aureobasidium pullulans. Journal Applied Microbiology. 2009 Aug; 107(2):691-8. doi: 10.1111/j.1365-2672.2009.04247.x.
19. Zheng W, Shi F Isolation and identification of a new dicoumarin from the roots of Daphne genkwa.Yao Xue Xue Bao. 2004 Dec; 39(12):990-2.
20. Shi F, Li C, Xia M, Miao K, Zhao Y, Tu S, Zheng W, Zhang G, Ma N. Green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives and evaluation of their antioxidant and cytotoxic activities. Bioorg Med Chem Lett. 2009 Oct 1; 19(19):5565-8. doi: 10.1016/j.bmcl.2009.08.046.
21. Zheng W, Zhang M, Zhao Y, Miao K, Jiang H. NMR-based metabonomic analysis on effect of light on production of antioxidant phenolic compounds in submerged cultures of Inonotus obliquus. Bioresource Technology. 2009 Oct;100(19):4481-7. doi: 10.1016/j.biortech.2009.04.027.
22. Zhao C, Zheng W, Li M. The interaction of berberine and human serum albumin. Guang Pu Xue Yu Guang Pu Fen Xi. 2004 Jan;24(1):111-3
23. Zheng W, Shi F. Three biflavonoids from ethanol extract of the root of Daphne genkwa. Yao Xue Xue Bao. 2005 May; 40(5):438-42.
24. Cao D, Li M, Xue R, Zheng W, Liu Z, Wang X. Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. Life Sciences. 2005 Nov 19; 78(1):74-81.
25. Zheng W, Chen C, Cheng Q, Wang Y, Chu C. Oral administration of exopolysaccharide from Aphanothece halophytica (Chroococcales) significantly inhibits influenza virus (H1N1)-induced pneumonia in mice. International Immunopharmacology. 2006 Jul; 6(7):1093-9.
26. Zheng W, Gao X, Chen C, Tan R. Total flavonoids of Daphne genkwa root significantly inhibit the growth and metastasis of Lewis lung carcinoma in C57BL6 mice. International Immunopharmacology. 2007 Feb; 7(2):117-27. Epub 2006 Aug 4.
27. Li M, Ge H, Kong X, Zheng W, Liu Z. Induction of apoptosis in pheochromocytoma (PC12) cells exposed to eicosapentaenoic acid in vitro. Indian Journal of Biochemistry and Biophysics. 2005 Aug; 42(4):222-7
28. Zheng W, Chen C, Wang X, Bao K. Effects of potassium iodide on the growth and metabolite accumulation of two planktonic diatoms. Journal of Applied Phycology 2005, 17: 355-362
29. Tan R, Zheng W, Tang H Biologically active substances from Artemisia L. Planta Medica 1998, 64：295-302
30. Tan R, Lu H, Wolfender J, Yu, T, Zheng W, Yang L, Gafner S, Hostettmann K. Mono- and sesquiterpene lactones and antifungal constituents from Artemisia species. Planta Medica 1998, 64: 234-236
31. Zheng W, Cui Z, Zhu Q. Cytotoxicity and antiviral activity of the compounds from Euphorbia kansui. Planta Medica 1998, 64: 754-756
32. Zheng W, Tan R, Liu Z. Two flavones from Artemisia giraldii and their antimicrobial activity. Planta Medica 30. 1996, 60: 160-16230.
33. Zheng W, Tan R, Liu Z. A new antimicrobial sesquiterpene lactone from Artemisia giraldii.
Spectroscopy Letters 1996, 29: 1589-1597